In this habilitation à diriger des recherches (HDR), I review a decade of research work in the fields of Model-Driven Engineering (MDE) and Software Language Engineering (SLE). I propose contributions to support a language-oriented modeling, with the particular focus on enabling early validation & verification (V&V) of software-intensive systems. I first present foundational concepts and engineering facilities which help to capture the core domain knowledge into the various heterogeneous concerns of DSMLs (aka. metamodeling in the small), with a particular focus on executable DSMLs to automate the development of dynamic V&V tools. Then, I propose structural and behavioral DSML interfaces, and associated composition operators to reuse and integrate multiple DSMLs (aka. metamodeling in the large). In these research activities I explore various breakthroughs in terms of modularity and reusability of DSMLs. I also propose an original approach which bridges the gap between the concurrency theory and the algorithm theory, to integrate a formal concurrency model into the execution semantics of DSMLs. All the contributions have been implemented in software platforms — the language workbench Melange and the GEMOC studio – and experienced in real-world case studies to assess their validity. In this context, I also founded the GEMOC initiative, an attempt to federate the community on the grand challenge of the globalization of modeling languages.