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Preprints, Working Papers, ... Year : 2007

Nonequilibrium phase transition in scattered cell communities coupled by auto/paracrine-like signalling

Abstract

Auto/paracrine cell-to-cell communications via diffusive messengers can be coupled to a positive feedback loop in which cell stimulation by a messenger results in the production of new messengers. This yields a potential mechanism for relay transmission of the emitted message. This paper investigates the influence of noise on this mutual coupling of the cells with their environment, using numerical simulations of a stochastic minimal model. The results demonstrate that the deterministic (mean-field) approximation of this stochastic process fails short of predicting its behaviour because of the presence of strong noise-induced fluctuations. Instead, the behaviour of the model can be explained by the occurrence of a nonequilibrium phase transition, which is found to be in the universality class of directed percolation. This provides a theoretical framework to understand signal transmission in these stochastic systems.
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Dates and versions

inria-00201086 , version 1 (23-12-2007)

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  • HAL Id : inria-00201086 , version 1

Cite

Hugues Berry. Nonequilibrium phase transition in scattered cell communities coupled by auto/paracrine-like signalling. 2007. ⟨inria-00201086⟩
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