Identification of reaction networks for bioprocesses: determination of a partially unknown pseudo-stoichiometric matrix
Abstract
In this paper we propose a methodology to determine the structure of the pseudo-stoichiometric co- efficient matrix K in a mass balance based model and to identify its coefficients from a set of available data. The first stage consists in estimating the number of re- actions that must be taken into account to represent the main mass transfer within the bioreactor. This provides the dimension of K. Then we propose a method to di- rectly determine the structure of the matrix (i.e. mainly its zeros and the signs of its coefficients). These meth- ods are illustrated with simulations of a process of lipase production from olive oil by Candida rugosa.
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