Coupling the Cell cycle and the Circadian Cycle - Inria - Institut national de recherche en sciences et technologies du numérique Access content directly
Reports (Research Report) Year : 2006

Coupling the Cell cycle and the Circadian Cycle

Laurence Calzone
Sylvain Soliman

Abstract

Cancer treatments based on the administration of medicines at different times of the day have been shown to be more efficient against malign cells and less damaging towards healthy ones. These results might be related to the recent discovery of links between the circadian clock, (controlled by the light/dark cycle of a day), and the cell cycle. However, if many models have been developed to describe both of these cycles, to our knowledge none has described a real interaction between them. We will try to establish a relation at a molecular level and we will then study the conditions of entrainment in period of these cycles with the modeling environment BIOCHAM. In other words, we will search how and where in the parameter space of our model the two cycles get synchronized. This technical report will insist on the conditions of entrainment of the cell cycle by the circadian cycle via a common protein kinase WEE1.

Domains

Other [cs.OH]
Fichier principal
Vignette du fichier
RR-5835.pdf (380.35 Ko) Télécharger le fichier

Dates and versions

inria-00070191 , version 1 (19-05-2006)

Identifiers

  • HAL Id : inria-00070191 , version 1

Cite

Laurence Calzone, Sylvain Soliman. Coupling the Cell cycle and the Circadian Cycle. [Research Report] RR-5835, INRIA. 2006, pp.15. ⟨inria-00070191⟩
103 View
265 Download

Share

Gmail Facebook X LinkedIn More