Optimal cell behavior in time - Inria - Institut national de recherche en sciences et technologies du numérique Access content directly
Book Sections Year : 2023

Optimal cell behavior in time

Dafni Giannari
  • Function : Author
Diego A Oyarzún
  • Function : Author
Steffen Waldherr
  • Function : Author
Agustín G Yabo
  • Function : Author

Abstract

This is a chapter from the free textbook "Economic Principles in Cell Biology"

Microorganisms live in continually changing environments, which require them to develop adaptation strategies. These strategies have been profitably studied under the assumption that microorganisms have evolved to optimize one or several aspects of their adaptive response. The mathematical formalization of this assumption leads to dynamic optimization problems that can be solved by means of techniques from optimal control theory. The chapter discusses three example problems: dynamic optimization of enzyme expression in metabolic pathways, dynamic optimization of coarse-grained models of cellular growth, and dynamic flux balance analysis. The results obtained for these problems illustrate the interest of studying adaptation strategies from the perspective of dynamic optimization, and the strengths and weaknesses of this approach.

Fichier principal
Vignette du fichier
chapter-TIM-preprint.pdf (941.09 Ko) Télécharger le fichier
Origin : Files produced by the author(s)

Dates and versions

hal-04383880 , version 1 (05-04-2024)

Licence

Attribution

Identifiers

Cite

Hidde de Jong, Dafni Giannari, Diego A Oyarzún, Steffen Waldherr, Agustín G Yabo. Optimal cell behavior in time. Economic Principles in Cell Biology, Zenodo, 2023, ⟨10.5281/zenodo.8157066⟩. ⟨hal-04383880⟩
28 View
1 Download

Altmetric

Share

Gmail Facebook X LinkedIn More