Remanufacturing is a practice that postpones the product ‘end-of-life,’ returning the properties or features of a new product to a used product. This type of process represents an efficient circular economy strategy to extend product life, reducing its footprint. However, remanufacturing systems must overcome different challenges related to uncertainty and its impact on efficiency. In this sense, this study exposes a hybrid remanufacturing-manufacturing architecture with embedded features from cellular and reconfigurable manufacturing systems. The architecture was synthesized in a Mixed Integer Non-Linear optimization model, which defines the remanufacturing system configuring the cells and product families, balancing the workloads, establishing the scheduling sequence and quantifying the reconfigurability cost. The result is a self-adaptative system that maintains a continuous production rate by managing its capacity.