The digital transformation of society in recent years has led to a qualitatively new leap in the development of natural sciences. Currently, these new technologies allow the collection and processing of a huge amount of information and increase the growth of scientific production, parallel to fusing the boundaries between scientific disciplines. Hence, the created Earth observation centers are a natural prerequisite for facilitating these processes. This article presents our studies on the information system architecture of some of the leading Earth observation research centers, with a focus on capabilities for integration with other scientific infrastructures. We review an original solution based on hybrid service-microservice architecture being implemented in the National Geoinformation Center of Bulgaria, investigating some possible advantages it may provide for integration with other Earth observation centers.