The emergence of Real-Time Systems with increased connections to their environment has led to a greater demand in security for these systems. Memory corruption attacks, which modify the memory to trigger unexpected executions, are a significant threat against applications written in low-level languages. Data-Flow Integrity (DFI) is a protection that verifies that only a trusted source has written any loaded data. The overhead of such a security mechanism remains a major issue that limits its adoption. This article presents RT-DFI, a new approach that optimizes the Data-Flow Integrity to reduce its overhead on the Worst-Case Execution Time. We model the number and order of the checks and use an Integer Linear Programming solver to optimize the protection on the Worst-Case Execution Path. Our approach protects the program against many memory-corruption attacks, including Return-Oriented Programming and Data-Only attacks. Moreover, our experimental results show that our optimization reduces the overhead by 7% on average compared to a state-of-the-art implementation.