Asthma is the first chronic disease in children: that concerns 10% of them. This is a real public health issue, because its frequency and gravity increase since 2000’s in this population. The major identified problem in asthma kids is the low rate of treatment adherence (50%). To increase adherence rate, there is some strategies as therapeutic education programs and numerical technologies as serious games or mobile applications but those learning systems are the same for all children, and it is proved that personalized program is more efficient than generic learning. In first step, we created a web responsive application composed by several interactive contents linked to asthma (based on criteria learnt in asthma therapeutic education) and displayed to different forms: learning activities with quiz, short games and videos. In a participatory design approach, the interfaces are tailored to children : they had been designed with iterative and user-centered methods. Moreover, asthma experts validated all the proposed content in the application and it was tested by asthma kids. In a preliminary study, we experimented usability, motivation and knowledge of few contents on 40 control children in choice/no-choice conditions. Observations showed KidBreath was easy to use, children were more motivated using it and acquire more knowledge in the choice condition rather no-choice. Later, to personalize learning activities linked to asthma, we have the objective to integrate learning optimization algorithm as an intelligent tutoring system in KidBreath.