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Journal Articles Cognitive Neurodynamics Year : 2012

The population firing rate in the presence of GABAergic tonic inhibition in single neurons and application to general anaesthesia

Axel Hutt

Abstract

Tonic inhibition has been found experimentally in single neurons and a ects the activity of neural populations. This kind of inhibition is supposed to set the background or resting level of neural activity and plays a role in the brains arousal system, e.g. during general anaesthesia. The work shows how to involve tonic inhibition in population rate-coding models by deriving a novel transfer function. The analytical and numerical study of the novel transfer function reveals the impact of tonic inhibition on the population ring rate. Finally, a rst application to a recent neural eld model for general anaesthesia discusses the origin of the loss of consciousness during anaesthesia
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Dates and versions

hal-00640064 , version 1 (10-11-2011)

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Axel Hutt. The population firing rate in the presence of GABAergic tonic inhibition in single neurons and application to general anaesthesia. Cognitive Neurodynamics, 2012, 6 (3), pp.227-237. ⟨10.1007/s11571-011-9182-9⟩. ⟨hal-00640064⟩
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