Interoperability is a key and challenging requirement in today's and future systems, which are often characterized by an extreme level of heterogeneity. To build an interoperability solution between the networked systems populating the environment, both their functional and non-functional requirements have to be met. Because of the continuous evolution of such systems, mechanisms that are fixed a-priori are inadequate to achieve interoperability. In such challenging settings, on-the-fly approaches are best suited. This paper presents, as an interoperability solution, an approach that integrates an automated technique for the synthesis of mediator protocols with a monitoring mechanism. The former aims to provide interoperability taking care of functional characteristics of the networked systems, whereas the latter makes it possible to assess the non-functional characteristics of the connected system.