The CONNECT Integrated Project aims at enabling continuous composition of networked systems to respond to the evolution of functionalities provided to and required from the networked environment. CONNECT aims at dropping the interoperability barrier by adopting a revolutionary approach to the seamless networking of digital systems, that is, synthesizing on-the-fly the connectors via which networked systems communicate. The resulting emergent connectors are effectively synthesized according to the behavioral semantics of application- down to middleware-layer protocols run by the interacting parties. The role of work package WP3 is to devise automated and compositional approaches to connector synthesis, which can be performed at run-time. Given the respective interaction behavior of networked systems, we want to synthesize the behavior of the connector(s) needed for them to interact. These connectors serve as mediators of the networked systems' interaction at both application and middleware layers. In this deliverable, we set the scene for a formal theory of the automated synthesis of application- and middleware-layer protocol mediators. We formally characterize mediating connectors between mismatching application-layer protocols by rigorously defining the necessary conditions that must hold for protocols to be mediated. The outcome of this formalization is the definition of two relationships between heterogenous protocols: matching and mapping. The former is concerned with checking whether a mediator letting two protocols interoperate exists or not. The latter concerns the algorithm that should be executed to synthesize the required mediator. Furthermore, we analyze the different dimensions of interoperability at the middleware layer and exploit this analysis to formalize existing solutions to middleware-layer interoperability. Since the work on application-layer mediator synthesis is based on the assumption that a model of the interaction protocol for a networked system is dynamically discovered, we finally present an approach, based on data-flow analysis and testing, for the automated elicitation of application-layer protocols from software implementations. This approach presents similarities, but also several differences, with the work of work package WP4 (protocol learning). Furthermore, it allowed us to proceed in parallel with the work of WP4 and to state the requirements that the learning approaches have to satisfy to enable mediator synthesis. For this reason, we keep this work separate from the work on protocol learning and discuss it in this deliverable. All the approaches mentioned above are applied to several examples and scenarios.