The deconvolution of blurred and noisy satellite images is an ill-posed inverse problem, which can be regularized within a Bayesian context by using an a priori model of the reconstructed solution. Homogeneous regularization models do not provide sufficiently satisfactory results, since real satellite data show spatially variant characteristics. We propose here to use an inhomogeneous model, and we study different methods to estimate its space-variant parameters. The chosen estimator is the Maximum Likelihood (ML). We show that this estimator, when computed on the corrupted image, is not suitable for image deconvolution, because it is not robust to noise. Then we show that the estimation is correct only if it is made from the original image. Since this image is unknown, we need to compute an approximati- on of sufficiently good quality to provide useful estimation results. Finally we detail an hybrid method used to estimate the space-variant parameters from an image deconvolved by a wavelet-based algorithm, in order to reconstruct the image. The obtained results simultaneously exhibit sharp edges, correctly restored textures and a high SNR in homogeneous areas, since the proposed technique adapts to the local characteristics of the data. A comparison with linear and non-linear concurrent algorithms is also presented to illustrate the efficiency of the proposed method.