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Article Dans Une Revue Physical Review E : Statistical, Nonlinear, and Soft Matter Physics Année : 2005

Adsorption-induced conformational changes in protein diffusion-aggregation surface assemblies

Résumé

Two-dimensional rigid colloid aggregation models may be applied to protein layers when no large conformational change is involved. Yet, following adsorption, several proteins undergo a conformational transition that may be involved in aggregative structures. Our focus here is how a conformational change might influence surface clustering in a diffusion-aggregation model. We propose a model including diffusion, aggregation, and unfolding of proteins that are randomly adsorbed onto a surface. Our model allows simulating the case where protein-protein interaction favors unfolding and the case where this interaction prevents it. We study the effect of a simple disk-to-rod unidirectional unfolding and investigate the morphology of the resulting clusters in the diffusion- and reaction-limited regimes. A rich variety of structures is produced, with fractal dimension differing from that in universal diffusive aggregation models. Increasing unfolding probability shifts the system from the neighbor-induced to the neighbor-prevented unfolding regime. The intermediate structures that arise from our model could be helpful in understanding the assembly of different observed protein structures.
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Dates et versions

inria-00001064 , version 1 (30-01-2006)

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  • HAL Id : inria-00001064 , version 1

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Hugues Berry, Delphine Pellenc, Olivier Gallet. Adsorption-induced conformational changes in protein diffusion-aggregation surface assemblies. Physical Review E : Statistical, Nonlinear, and Soft Matter Physics, 2005, 72, pp.051904. ⟨inria-00001064⟩
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