The paper presents an innovative mobile application enabling the security and safety inspectors of Oil & Gas Transportation to receive in their car all the real-time data necessary to drive them to the visual evidence of the truck driver’s unsafe or dishonest activities. The application works on the top of an IoT platform managing a sensor network installed on over 3,000 tank trucks. The paper presents the application domain, the architecture, the implementation, and the experiments, also reporting a set of quantitative experimental results that validate the application effectiveness. The results also qualify the application as one of the first cases of real-time Cyber-Physical Systems for Logistics and Transportation Safety and Security validated for the measured impact on the operations, and not just in terms of scenarios or technology potentials.