An elastic-degenerate (ED) string T is a sequence of n sets T [1],. .. , T [n] containing m strings in total whose cumulative length is N. We call n, m, and N the length, the cardinality and the size of T , respectively. The language of T is defined as L(T) = {S1 • • • Sn : Si ∈ T [i] for all i ∈ [1, n]}. ED strings have been introduced to represent a set of closely-related DNA sequences, also known as a pangenome. The basic question we investigate here is: Given two ED strings, how fast can we check whether the two languages they represent have a nonempty intersection? We call the underlying problem the ED String Intersection (EDSI) problem. For two ED strings T1 and T2 of lengths n1 and n2, cardinalities m1 and m2, and sizes N1 and N2, respectively, we show the following: There is no O((N1N2) 1-ϵ)-time algorithm, thus no O (N1m2 + N2m1) 1-ϵ-time algorithm and no O (N1n2 + N2n1) 1-ϵ-time algorithm, for any constant ϵ > 0, for EDSI even when T1 and T2 are over a binary alphabet, unless the Strong Exponential-Time Hypothesis is false. There is no combinatorial O((N1 + N2) 1.2-ϵ f (n1, n2))-time algorithm, for any constant ϵ > 0 and any function f , for EDSI even when T1 and T2 are over a binary alphabet, unless the Boolean Matrix Multiplication conjecture is false. An O(N1 log N1 log n1 + N2 log N2 log n2)-time algorithm for outputting a compact (RLE) representation of the intersection language of two unary ED strings. In the case when T1 and T2 are given in a compact representation, we show that the problem is NP-complete. An O(N1m2 + N2m1)-time algorithm for EDSI. An Õ(N ω-1 1 n2 + N ω-1 2 n1)-time algorithm for EDSI, where ω is the exponent of matrix multiplication; the Õ notation suppresses factors that are polylogarithmic in the input size. We also show that the techniques we develop have applications outside of ED string comparison.