Criteria for the Regression of Pediatric Mastocytosis: A Long-Term Follow-Up
Résumé
Mastocytosis is a neoplastic condition characterized by the accumulation of mast cells (MCs) in 1 or more organ. Adults tend to have persistent, systemic mastocytosis, whereas MC infiltration in children is usually limited to the skin and typically regresses after several years. Both adults and children could display mast cell activation symptoms (MCASs) due to MC mediator release. In more than 85% of both adult and pediatric cases, KIT mutations are present, with the KIT D816V mutation being present in most affected adults but in only half the affected children.
Mots clés
clinical research / practice
complication
diagnostic techniques and imaging: ultrasound
infection and infectious agents - viral
infectious disease
kidney disease: immune / inflammatory
kidney transplantation / nephrology
pediatrics
recipient selection
Cutaneous mastocytosis
KIT mutation
Mast cell
Mast cell activation symptom
Pediatric mastocytosis
Prognosis
Tryptase