In today’s dynamic digitalization environment, companies must continually seek to make improvements while still retaining their current position. This requires the use of new sustainable models that will ensure design efforts, addresses customer and societal needs during the entire product lifecycle phases (PLC). To succeed in improvements Design for X (DFX) requires addressing these issues across multiple factors X’s that generates value for each stakeholder in the value chain. However, a variety of DFX techniques have been developed which makes the practitioners and researchers facing great difficulty to decide which techniques to use in which PLC phase to ensure which business strategy. In this respect, the aim of this paper is first to present a review of the most used and applicable DFX techniques to the sustainability dimension and PLC phases. Then, to define the hierarchical structure of the relationships among the identified DFX techniques and to analyze the characteristics power of each one, “interpretive structural modeling” (ISM) and MICMAC are implemented. The proposed framework would be useful for academics and practitioners because it demonstrates the interrelationships of DFX techniques and also offers an additional viewpoint for handling these techniques using the integrated ISM-MICMAC approach. The major implications and limitations are discussed.