The adoption of Industry 4.0 technologies is slow and lacks homogeneity across the manufacturing landscape. Challenges arise from legacy IT systems, or a low level of digitization leading to difficult integration processes, or simply the fear of investing too much in building the necessary infrastructure versus the uncertainty of the potential benefits. The market has also become more demanding, both in terms of competition and customer requirements, so that more and more manufacturers are faced with the demand for high production flexibility, high quality, and low operating costs. This paper aims to address the implementation complexity of a cyber-physical production system for zero-defect manufacturing in dynamic, high-value, high-mix, and low-volume contexts where the level of digitalization is still low, or the IT infrastructure is rigid.