Inter-individual differences in cell composition across the ventricular wall may explain variability in ECG response to serum potassium and calcium variations - Inria - Institut national de recherche en sciences et technologies du numérique Access content directly
Conference Papers Year : 2022

Inter-individual differences in cell composition across the ventricular wall may explain variability in ECG response to serum potassium and calcium variations

Abstract

Non-invasive monitoring of serum potassium ([K + ]) and calcium ([Ca 2+ ]) concentration can help to prevent arrhythmia in kidney patients. Current electrocardiogram (ECG) markers, including the T wave width (T w) and its time-warped temporal morphological variability (d U w), correlate significantly with [K + ] and [Ca 2+ ] but these relations vary strongly between patients. We hypothesized that inter-individual differences in cell type distribution across the ventricular wall can explain this variability. We computed T w and d U w in simulated ECGs from a human heart-torso model at different proportions of endo-, mid-, and epicardial cells, while varying [K + ] (3 to 6.2 mM) and [Ca 2+ ] (1.4 to 3.2 mM). Electrical activity was simulated with a reaction-diffusion model with modified Ten Tusscher-Panfilov dynamics. Results were compared to data from 29 patients. T w and d U w correlated strongly with [K + ] (absolute median Pearson coefficient r = 0.70 to 0.93) and [Ca 2+ ] (r = 0.69 to 0.86) in simulations and in patients. Different cell type distributions reproduced inter-patient variability, with the same sign and magnitude of r. In conclusion, the inter-patient variability in the relation between serum electrolytes and their ECG markers can indeed be explained by inter-individual differences in cell type distribution across the ventricular wall.
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Dates and versions

hal-03936957 , version 1 (12-01-2023)

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  • HAL Id : hal-03936957 , version 1

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Hassaan Bukhari, Carlos Sánchez, Pablo Laguna, Mark Potse, Esther Pueyo. Inter-individual differences in cell composition across the ventricular wall may explain variability in ECG response to serum potassium and calcium variations. Computing in Cardiology 2022, Sep 2022, Tampere, Finland. ⟨hal-03936957⟩
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