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Article Dans Une Revue Cancer Chemotherapy and Pharmacology Année : 2022

Impact of pharmacogenetics on variability in exposure to oral vinorelbine among pediatric patients: a model‐based population pharmacokinetic analysis

Résumé

Better understanding of pharmacokinetics of oral vinorelbine (VNR) in children would help predicting drug exposure and, beyond, clinical outcome. Here, we have characterized the population pharmacokinetics of oral VNR and studied the factors likely to explain the variability observed in VNR exposure among young patients.
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Dates et versions

hal-03923671 , version 1 (04-01-2023)

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Mourad Hamimed, Pierre Leblond, Aurélie Dumont, Florence Gattacceca, Emmanuelle Tresch-Bruneel, et al.. Impact of pharmacogenetics on variability in exposure to oral vinorelbine among pediatric patients: a model‐based population pharmacokinetic analysis. Cancer Chemotherapy and Pharmacology, 2022, 90 (1), pp.29-44. ⟨10.1007/s00280-022-04446-y⟩. ⟨hal-03923671⟩
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