Clinically Meaningful <scp>Magnetic Resonance</scp> Endpoints Sensitive to Preataxic Spinocerebellar Ataxia Types <scp>1</scp> and <scp>3</scp> - Inria - Institut national de recherche en sciences et technologies du numérique
Journal Articles Annals of Neurology Year : 2022

Clinically Meaningful Magnetic Resonance Endpoints Sensitive to Preataxic Spinocerebellar Ataxia Types 1 and 3

S H Subramony
Gülin Öz

Abstract

Objective: This study was undertaken to identify magnetic resonance (MR) metrics that are most sensitive to early changes in the brain in spinocerebellar ataxia type 1 (SCA1) and type 3 (SCA3) using an advanced multimodal MR imaging (MRI) protocol in the multisite trial setting. Methods: SCA1 or SCA3 mutation carriers and controls (n = 107) underwent MR scanning in the US-European READISCA study to obtain structural, diffusion MRI, and MR spectroscopy data using an advanced protocol at 3T. Morphometric, microstructural, and neurochemical metrics were analyzed blinded to diagnosis and compared between preataxic SCA (n = 11 SCA1, n = 28 SCA3), ataxic SCA (n = 14 SCA1, n = 37 SCA3), and control (n = 17) groups using nonparametric testing accounting for multiple comparisons. MR metrics that were most sensitive to preataxic abnormalities were identified using receiver operating characteristic (ROC) analyses.
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Dates and versions

hal-03917995 , version 1 (02-01-2023)

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Jayashree Chandrasekaran, Emilien Petit, Young Woo Park, Sophie Tezenas Du Montcel, James M Joers, et al.. Clinically Meaningful Magnetic Resonance Endpoints Sensitive to Preataxic Spinocerebellar Ataxia Types 1 and 3. Annals of Neurology, 2022, ⟨10.1002/ana.26573⟩. ⟨hal-03917995⟩
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