The widespread adoption of Industry 4.0 technologies in factories are transforming manufacturing operations management. Multiple resources are interconnected, massive data are real-timely collected by smart devices to provide visibility and traceability. It is generally acknowledged that real-time data are beneficial for manufacturing operations management. How to utilize these data for facilitating production and intralogistics (PiL) operations management is an emerging challenge. This study proposes a new concept, operation twins, for achieving synchronized PiL operations based on three dimensions of synchronization (cyber-physical synchronization, spatial-temporal synchronization, and data-driven decisions synchronization).