Model insights into EEG origin under transcranial direct current stimulation (tDCS) in the context of psychosis - Inria - Institut national de recherche en sciences et technologies du numérique Access content directly
Preprints, Working Papers, ... Year : 2022

Model insights into EEG origin under transcranial direct current stimulation (tDCS) in the context of psychosis

Abstract

Schizophrenia is a psychotic disease that develops progressively over years with a transition from prodromal to psychotic state associated with a disruption in brain activity. Transcranial Direct Current Stimulation (tDCS), known to alleviate pharmaco-resistant symptoms in patients suffering from schizophrenia, promises to prevent such a psychotic transition. To understand better how tDCS affects brain activity, we propose a neural cortico-thalamo-cortical (CTC) circuit model involving the Ascending Reticular Arousal System (ARAS) that permits to describe major impact features of tDCS, such as excitability for short-duration stimulation and electroencephalography (EEG) power modulation for long-duration stimulation. To this end, the mathematical model relates stimulus duration and Long-Term Plasticity (LTP) effect, in addition to describing the temporal LTP decay after stimulus offset. Moreover, we reproduce successfully EEG-power modulation under tDCS in a ketamine-induced psychosis model and confirm the N-methyl-d-aspartate (NMDA) receptor hypofunction hypothesis in the etiopathophysiology of schizophrenia. The model description points to an important role of the ARAS and the δ− rhythm synchronicity in CTC circuit in early stage psychosis.
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Dates and versions

hal-03548590 , version 1 (30-01-2022)

Identifiers

  • HAL Id : hal-03548590 , version 1

Cite

Joséphine Riedinger, Axel Hutt. Model insights into EEG origin under transcranial direct current stimulation (tDCS) in the context of psychosis. 2022. ⟨hal-03548590⟩
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