This work focuses on a four-equation model for simulating two-phase mixtures with phase transition. The main assumption consists in a homogeneous temperature, pressure and velocity fields between the two phases. In particular, we tackle the study of time dependent problems with strong discontinuities and phase transition. This work presents the extension of a non-conservative residual distribution scheme to solve a four-equation two-phase system with phase transition. This non-conservative formulation allows avoiding the classical oscillations obtained by many approaches, that might appear for the pressure profile across contact discontinuities. The proposed method relies on a Finite Volume based Residual Distribution scheme which is designed for an explicit second-order time stepping. We test the non-conservative Residual Distribution scheme on several benchmark problems and assess the results via a cross-validation with the approximated solution obtained via a conservative approach, based on an HLLC solver. Furthermore, we check both methods for mesh convergence and show the effective robustness on very severe test cases, that involve both problems with and without phase transition.