Background: Ambient Assisted Living (AAL) technology is expected as a promising way for prolonging the aging in place. Very few evidence-based results are provided support to its real value, notably for frail older adults who have high risk of autonomy loss and of entering in nursing home. Objective: HomeAssist (HA) is a human-centered AAL platform offering a large set of applications for three main age-related need domains (Activities of Daily Living, Safety and Social participation), relying on a basic set of entities (sensors, actuators...). The HA intervention involves monitoring as well as assistive services to support independent living at home. The primary outcomes measures are related to aging in place in terms of effectiveness (institutionalization and hospitalization rates) and efficiency (everyday functioning indices). Secondary outcomes measures include indices of frailty, cognitive functioning, and psychosocial health of participants and their caregivers. Every 6 months, user experience and attitudes towards HA are also collected in equipped participants. Concomitantly, HA usages are collected. Methods: A study assessing the HA efficacy has been designed and is now conducted with 131 older adults aged 81.9 (±6.0) years (from autonomous to frail) who lived alone. The study design is quasi-experimental with a duration of 12 months optionally extensible to 24 months. It includes equipped participants, matched with non-equipped participants (n= 474). Followup assessments occurred at 0, 12 and 24 months. Results: The expected results are to inform the AAL value for independent living, but also to yield informed analysis on AAL usages and adoption in frail older individuals.