In Japan, there are many flood and tsunami disasters caused by typhoons, heavy rains and earthquakes. In this case, the residents have an evacuation time to evacuate to shelters after evacuation alerts from a governmental office. However, the limited capacity of shelters and the delay in the rescue of support required people such as elderly and disabled people, the disaster can cause a serious damage. In order to prevent such a damage, we propose an evacuation support system that enables the information sharing of shelters’ condition, the support required people and the support team. In this paper, we evaluated the effects of the evacuation support system by multi-agent simulation in a regional disaster. As a result of the simulation for a case study in a regional area with three evacuation shelters on Yahaba town in Iwate Prefecture, Japan, we confirmed that if we had enough evacuation time, the evacuation support system had an effect to increase the number of the evacuees.