Exploratory analysis of the genetics of impulse control disorders in Parkinson's disease using genetic risk scores - Inria - Institut national de recherche en sciences et technologies du numérique Access content directly
Journal Articles Parkinsonism & Related Disorders Year : 2021

Exploratory analysis of the genetics of impulse control disorders in Parkinson's disease using genetic risk scores

Abstract

Objective: To study the association between impulse control disorders (ICDs) in Parkinsons disease (PD) and genetic risk scores (GRS) for 40 known or putative risk factors (e.g. depression, personality traits). Background: In absence of published genome-wide association studies (GWAS), little is known about the genetics of ICDs in PD. GRS of related phenotypes, for which large GWAS are available, may help shed light on the genetic contributors of ICDs in PD. Methods: We searched for GWAS on European ancestry populations with summary statistics publicly available for a broad range of phenotypes, including other psychiatric disorders, personality traits, and simple phenotypes. We separately tested their predictive ability in two of the largest PD cohorts with clinical and genetic available: the Parkinsons Progression Markers Initiative database (N = 368, 33% female, age range = [33 − 84]) and the Drug Interaction With Genes in Parkinsons Disease study (N = 373, 40% female, age range = [29 − 85]). Results: We considered 40 known or putative risk factors for ICDs in PD for which large GWAS had been published. After Bonferroni correction for multiple comparisons, no GRS or the combination of the 40 GRS were significantly associated with ICDs from the analyses in each cohort separately and from the meta-analysis. Conclusion: Albeit unsuccessful, our approach will gain power in the coming years with increasing availability of genotypes in clinical cohorts of PD, but also from future increase in GWAS sample sizes of the phenotypes we considered. Our approach may be applied to other complex disorders, for which GWAS are not available or limited.
Fichier principal
Vignette du fichier
Manuscript.pdf (604.7 Ko) Télécharger le fichier
Origin Files produced by the author(s)

Dates and versions

hal-03298502 , version 1 (23-07-2021)
hal-03298502 , version 2 (21-10-2022)

Identifiers

Cite

Johann Faouzi, Baptiste Couvy-Duchesne, Samir Bekadar, Olivier Colliot, Jean-Christophe Corvol. Exploratory analysis of the genetics of impulse control disorders in Parkinson's disease using genetic risk scores. Parkinsonism & Related Disorders, 2021, 86, pp.74 - 77. ⟨10.1016/j.parkreldis.2021.04.003⟩. ⟨hal-03298502v2⟩
104 View
246 Download

Altmetric

Share

Gmail Mastodon Facebook X LinkedIn More