Forecasting air pollution is considered as an essential key for early warning and control management of air pollution, especially in emergency situations, where big amounts of pollutants are quickly released in the air, causing considerable damages. Predicting pollution in such situations is particularly challenging due to the strong dynamic of the phenomenon and the various spatio-temporal factors affecting air pollution dispersion. In addition, providing uncertainty estimates of prediction makes the forecasting model more trustworthy, which helps decision-makers to take appropriate actions with more confidence regarding the pollution crisis. In this study, we propose a multi-point deep learning model based on convolutional long short term memory (ConvLSTM) for highly dynamic air quality forecasting. ConvLSTM architectures combines long short term memory (LSTM) and convolutional neural network (CNN), which allows to mine both temporal and spatial data features. In addition, uncertainty quantification methods were implemented on top of our model’s architecture and their performances were further excavated. We conduct extensive experimental evaluations using a real and highly dynamic air pollution data set called Fusion Field Trial 2007 (FFT07). The results demonstrate the superiority of our proposed deep learning model in comparison to state-of-the-art methods including machine and deep learning techniques. Finally, we discuss the results of the uncertainty techniques and we derive insights.