National and economic benefits of mobile phone use in developing countries has been a well-articulated research domain over an extended period. This can be attributed to the ubiquitous nature of mobile phones and their increased penetration in developing nations. However, the potential benefits of mobile phones for empowerment and well-being of people with disability (PWD) has been ignored. This paper focuses on the well-being of the physically challenged in Nigeria and how mobile phones can be employed to empower them. The link between ICT and human development has been well researched, but minimal research has attempted to link ICT, mobile phone and disability using the Capability Approach as a theoretical lens. The critical realist ethnographic study approach is employed in this study to show how mobile phones can be used to empower and impact on the well-being of the physically challenged. Data were collected from the Adamawa skill acquisition center for persons with disability, Nigeria. It is argued that mobile phones have the capabilities to empower and impact on the well-being of the physically challenged. Thus, the findings illustrate that mobile phones play significant roles in the well-being and empowerment of the physically challenged.