Human information interaction is a dynamic and complex process and is affected by various factors including social and cognitive factors. This study provides a new approach to study human information interaction from a social semiotic perspective and views human information interaction as a social semiotic process. Language, as a most important information carrier, is viewed as a social semiotic system and plays a key role in human information interaction. It not only carries and stores information, but also construes information. This study analyzes the role of language in human information interaction by exploring human judgment in native language and foreign language, which implies that language affects human judgement and thinking that conducts human information activities. The effect depends on the natural logic which limits the meaning-making process of language. Language, to an extent, affects the meaning creation at information interface through which human interact with information content and process information.