Anatomically-induced Fibrillation in a 3D model of the Human Atria - Inria - Institut national de recherche en sciences et technologies du numérique Access content directly
Conference Papers Year : 2018

Anatomically-induced Fibrillation in a 3D model of the Human Atria


Atrial fibrillation (AF) requires both a trigger and a sub-strate that can maintain a complex reentrant activity. In patients and in experimental models this substrate is provided by both electrical and structural remodeling. Since these processes overlap in time it is impossible to assess their individual contributions to AF maintenance experimentally. Therefore we studied the effect of electrical re-modeling alone on AF initiation in a realistic numerical model of the human atria. We attempted to initiate AF by rapid pacing in 10 different locations, both with and without electrical remodeling. The protocols were repeated twice, with small variations in calcium conductivity, so that in total 30 simulations with and 30 simulations without remodeling were performed. In models with electrical remodeling, functional conduction block at structural in-homogeneities induced AF in 27 % of the simulations. In models without electrical remodeling, AF could not be induced. We conclude that in the complex anatomy of the atria electrical remodeling alone increases the probability of AF substantially. This finding supports a mechanism whereby electrical remodeling, which occurs relatively fast, accelerates the slower but irreversible structural remodeling process.
Fichier principal
Vignette du fichier
finalpaper.pdf (4.87 Mo) Télécharger le fichier
Origin Files produced by the author(s)

Dates and versions

hal-01910674 , version 1 (01-11-2018)


  • HAL Id : hal-01910674 , version 1


Mark Potse, Ali Gharaviri, Simone Pezzuto, Angelo Auricchio, Rolf Krause, et al.. Anatomically-induced Fibrillation in a 3D model of the Human Atria. Computing in Cardiology, Sep 2018, Maastricht, Netherlands. ⟨hal-01910674⟩
83 View
100 Download


Gmail Mastodon Facebook X LinkedIn More