Aims Clinical application of patient-specific cardiac computer models requires fast and robust processing pipelines that can be seamlessly integrated into clinical workflows. We aim at building such a pipeline from computed tomography (CT) images to personalised cardiac electrophysiology (EP) model. The simulation output could be useful in the context of post-infarct ventricular tachycardia (VT) radio-frequency ablation (RFA) planning for pre-operative targets prediction. Methods The support for model personalisation is a patient-specific virtual three-dimensional heart obtained from CT images. Here the scar is identified as thinning of the myocardial wall on automatically computed thickness maps. We then use an Eikonal model of wave front propagation with reduced velocity in the damaged areas. An image-based vessel enhancement algorithm can automatically identify VT isthmuses. The personalised model is used for virtual pacing. Results We obtained a very fast pipeline that enables simulations in only a few minutes. It is fully automated starting from the semi-automated image segmentation phase. The computational time frame is compatible with the construction of a virtual pacing tool. In this tool, onset points and an optional directional block could be interactively selected. The directional block is a simple way to model tissue refractoriness. Output activation maps are compared with EP data acquired per-operatively. We show that this framework allows the reproduction of recorded re-entrant VT activation patterns. Conclusion Our simulation framework has an application in VT RFA intervention planning. It could be used to guide EP explorations and even predict ablation targets pre-operatively. This could reduce intervention duration and improve success rate. Condensed abstract Our goal is to build a fast and robust automated pipeline from computed tomography images to personalised cardiac electrophysiology simulations. We use myocardial wall thickness to parametrise the velocity of an Eikonal model of wave front propagation and reproduce electrophysiolog-ical data acquired during ventricular tachycardia radio-frequency ablation.