Direct parametric reconstruction with joint motion estimation/correction for dynamic brain PET data
Résumé
Direct reconstruction of parametric images from raw photon counts has been shown to improve the quantitative analysis of dynamic positron emission tomography (PET) data. However it suffers from subject motion which is inevitable during the typical acquisition time of 1-2 hours. In this work we propose a framework to jointly estimate subject head motion and reconstruct the motion-corrected parametric images directly from raw PET data, so that the effects of distorted tissue-to-voxel mapping due to subject motion can be reduced in reconstructing the parametric images with motion-compensated attenuation correction and spatially aligned temporal PET data. The proposed approach is formulated within the maximum likelihood framework, and efficient solutions are derived for estimating subject motion and kinetic parameters from raw PET photon count data. Results from evaluations on simulated [11C]raclopride data using the Zubal brain phantom and real clinical [18F]florbetapir data of a patient with Alzheimer's disease show that the proposed joint direct parametric reconstruction motion correction approach can improve the accuracy of quantifying dynamic PET data with large subject motion.
Mots clés
simulated [11C]raclopride data
spatially aligned temporal PET data
subject head motion
subject motion
time 1 h to 2 h
Zubal brain phantom
Attenuation
positron emission tomography
medical image processing
Alzheimer's disease
Biomedical imaging
biological tissues
biomechanics
diseases
motion correction
image reconstruction
maximum likelihood estimation
acquisition time
direct parametric reconstruction
distorted tissue-to-voxel mapping
dynamic brain PET data
Dynamic PET
dynamic positron emission tomography data
Dynamics
joint direct parametric reconstruction motion correction
joint motion estimation-correction
kinetic analysis
kinetic parameters
Kinetic theory
maximum likelihood framework
motion compensation
motion-compensated attenuation correction
motion-corrected parametric images
parametric images
PET reconstruction
phantoms
photon counting
Photonics
quantitative analysis
raw PET photon count data
raw photon counts
real clinical [18F]florbetapir data