Study protocol: Insight 46 – a neuroscience sub-study of the MRC National Survey of Health and Development
Christopher A. Lane
,
Thomas D. Parker
,
Dave M. Cash
,
Kirsty Macpherson
,
Elizabeth Donnachie
,
Heidi Murray-Smith
,
Anna Barnes
,
Suzie Barker
,
Daniel G. Beasley
(1)
,
Jose Bras
(2)
,
David Brown
,
Ninon Burgos
(1)
,
Michelle Byford
,
M. Jorge Cardoso
,
Ana Carvalho
(3)
,
Jessica Collins
,
Enrico de Vita
,
John C. Dickson
,
Norah Epie
,
Miklos Espak
,
Susie M. D. Henley
,
Chandrashekar Hoskote
,
Michael Hutel
,
Jana Klimova
,
Ian B. Malone
(4)
,
Pawel Markiewicz
,
Andrew Melbourne
,
Marc Modat
(1)
,
Anette Schrag
,
Sachit Shah
,
Nikhil Sharma
,
Carole H. Sudre
,
David L. Thomas
,
Andrew Wong
,
Hui Zhang
(5)
,
John Hardy
(6, 7)
,
Henrik Zetterberg
(8, 9, 4)
,
Sebastien Ourselin
(1)
,
Sebastian J. Crutch
(10)
,
Diana Kuh
(11)
,
Marcus Richards
,
Nick C. Fox
(10)
,
Jonathan M. Schott
(10)
1
CMIC -
Centre for Medical Image Computing
2 Department of Molecular Neurosciences
3 Instituto de Bioética, and Portuguese National Council for Ethics in Life Sciences [Porto, Portugal]
4 UCL Institute of Neurology, Queen Square [London]
5 Henan Agriculture University
6 Metacohorts Consortium
7 UCL - University College of London [London]
8 Sahlgrenska Academy at University of Gothenburg [Göteborg]
9 Sahlgrenska University Hospital [Gothenburg]
10 Department of Neurodegenerative Disease
11 MRC National Survey of Health and Development
2 Department of Molecular Neurosciences
3 Instituto de Bioética, and Portuguese National Council for Ethics in Life Sciences [Porto, Portugal]
4 UCL Institute of Neurology, Queen Square [London]
5 Henan Agriculture University
6 Metacohorts Consortium
7 UCL - University College of London [London]
8 Sahlgrenska Academy at University of Gothenburg [Göteborg]
9 Sahlgrenska University Hospital [Gothenburg]
10 Department of Neurodegenerative Disease
11 MRC National Survey of Health and Development
Christopher A. Lane
- Function : Author
Thomas D. Parker
- Function : Author
Dave M. Cash
- Function : Author
Kirsty Macpherson
- Function : Author
Elizabeth Donnachie
- Function : Author
Heidi Murray-Smith
- Function : Author
Anna Barnes
- Function : Author
Suzie Barker
- Function : Author
David Brown
- Function : Author
- PersonId : 757359
- ORCID : 0000-0002-8360-9721
Ninon Burgos
- Function : Author
- PersonId : 14646
- IdHAL : ninon-burgos
- ORCID : 0000-0002-4668-2006
- IdRef : 25099884X
Michelle Byford
- Function : Author
M. Jorge Cardoso
- Function : Author
Jessica Collins
- Function : Author
Enrico de Vita
- Function : Author
John C. Dickson
- Function : Author
Norah Epie
- Function : Author
Miklos Espak
- Function : Author
Susie M. D. Henley
- Function : Author
Chandrashekar Hoskote
- Function : Author
Michael Hutel
- Function : Author
Jana Klimova
- Function : Author
Pawel Markiewicz
- Function : Author
Andrew Melbourne
- Function : Author
Marc Modat
- Function : Author
- PersonId : 764549
- ORCID : 0000-0002-5277-8530
Anette Schrag
- Function : Author
Sachit Shah
- Function : Author
Nikhil Sharma
- Function : Author
Carole H. Sudre
- Function : Author
David L. Thomas
- Function : Author
Andrew Wong
- Function : Author
Henrik Zetterberg
- Function : Author
- PersonId : 763019
- ORCID : 0000-0003-3930-4354
Marcus Richards
- Function : Author
Abstract
Increasing age is the biggest risk factor for dementia, of which Alzheimer’s disease is the commonest cause. The pathological changes underpinning Alzheimer’s disease are thought to develop at least a decade prior to the onset of symptoms. Molecular positron emission tomography and multi-modal magnetic resonance imaging allow key pathological processes underpinning cognitive impairment – including β-amyloid depostion, vascular disease, network breakdown and atrophy – to be assessed repeatedly and non-invasively. This enables potential determinants of dementia to be delineated earlier, and therefore opens a pre-symptomatic window where intervention may prevent the onset of cognitive symptoms.