Study protocol: Insight 46 – a neuroscience sub-study of the MRC National Survey of Health and Development - Inria - Institut national de recherche en sciences et technologies du numérique Access content directly
Journal Articles BMC Neurology Year : 2017

Study protocol: Insight 46 – a neuroscience sub-study of the MRC National Survey of Health and Development

Christopher A. Lane
  • Function : Author
Thomas D. Parker
  • Function : Author
Dave M. Cash
  • Function : Author
Kirsty Macpherson
  • Function : Author
Elizabeth Donnachie
  • Function : Author
Heidi Murray-Smith
  • Function : Author
Anna Barnes
  • Function : Author
Suzie Barker
  • Function : Author
David Brown
Ninon Burgos
Michelle Byford
  • Function : Author
M. Jorge Cardoso
  • Function : Author
Jessica Collins
  • Function : Author
Enrico de Vita
  • Function : Author
John C. Dickson
  • Function : Author
Norah Epie
  • Function : Author
Miklos Espak
  • Function : Author
Susie M. D. Henley
  • Function : Author
Chandrashekar Hoskote
  • Function : Author
Michael Hutel
  • Function : Author
Jana Klimova
  • Function : Author
Pawel Markiewicz
  • Function : Author
Andrew Melbourne
  • Function : Author
Marc Modat
Anette Schrag
  • Function : Author
Sachit Shah
  • Function : Author
Nikhil Sharma
  • Function : Author
Carole H. Sudre
  • Function : Author
David L. Thomas
  • Function : Author
Andrew Wong
  • Function : Author
Marcus Richards
  • Function : Author

Abstract

Increasing age is the biggest risk factor for dementia, of which Alzheimer’s disease is the commonest cause. The pathological changes underpinning Alzheimer’s disease are thought to develop at least a decade prior to the onset of symptoms. Molecular positron emission tomography and multi-modal magnetic resonance imaging allow key pathological processes underpinning cognitive impairment – including β-amyloid depostion, vascular disease, network breakdown and atrophy – to be assessed repeatedly and non-invasively. This enables potential determinants of dementia to be delineated earlier, and therefore opens a pre-symptomatic window where intervention may prevent the onset of cognitive symptoms.

Dates and versions

hal-01827191 , version 1 (01-07-2018)

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Christopher A. Lane, Thomas D. Parker, Dave M. Cash, Kirsty Macpherson, Elizabeth Donnachie, et al.. Study protocol: Insight 46 – a neuroscience sub-study of the MRC National Survey of Health and Development. BMC Neurology, 2017, 17, pp.75. ⟨10.1186/s12883-017-0846-x⟩. ⟨hal-01827191⟩
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