Use of blended learning system in a structured manner results in achieving higher order skills in cognitive domain. However, there is a need to quantify skills improvements as the students go through lower level skills to higher level skills. To ascertain this progression, it is necessary to develop a mathematical model of learning which can indicate the effectiveness of teaching and learning methods on skills improvement. In this study, mathematical learning model has been developed, which predicts the students’ knowledge, depending on the amount of instruction they receive. It is expected that this model will enable development of direct correlation between teaching and learning methods, and the skills level attained by the students. The model is applied for different categories of learning. Parameters in the model are determined after least-square fitting has been applied on observed student learning data.