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Journal Articles Alzheimer's & Dementia : the Journal of the Alzheimer's Association Year : 2017

Preclinical Alzheimer's disease: a systematic review of the cohorts underlying the concept

Abstract

Preclinical Alzheimer's disease (AD) is a relatively recent concept describing an entity characterized by the presence of a pathophysiological biomarker signature characteristic for AD in the absence of specific clinical symptoms. There is rising interest in the scientific community to define such an early target population mainly due to failures of all recent clinical trials despite evidence of biological effects on brain amyloidosis for some compounds. A conceptual framework has recently been proposed for this preclinical phase of AD. However, few data exist on this silent stage of AD. We performed a systematic review in order to investigate how the concept is defined across studies. The review highlights the substantial heterogeneity concerning the three main determinants of preclinical AD: " normal cognition " , " cognitive decline " and " AD pathophysiological signature ". We emphasize the need for a harmonized nomenclature of the preclinical AD concept and standardized population-based and case-control studies using unified operationalized criteria.

Domains

Neuroscience
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Dates and versions

hal-01672859 , version 1 (27-12-2017)

Identifiers

Cite

Stéphane Epelbaum, Rémy Genthon, Enrica Cavedo, Marie Habert, Foudil Lamari, et al.. Preclinical Alzheimer's disease: a systematic review of the cohorts underlying the concept. Alzheimer's & Dementia : the Journal of the Alzheimer's Association, 2017, 13 (4), pp.454-467. ⟨10.1016/j.jalz.2016.12.003⟩. ⟨hal-01672859⟩
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