Research on antiretroviral therapy (ART) programs reveal that HIV positive patients who adhere to treatment substantially improve their life expectancy and lower the risk of progression to full-blown AIDS. While there is a significant body of research in the medical and social science fields on ART adherence, Information Systems (IS) research has paid little attention to this subject. Especially lacking is research on how Information and Communication Technology (ICT) based solutions can be developed to better support ART adherence programs. We argue in this paper that software platforms offer capabilities that can be leveraged to address more effectively the information management challenges associated with ART adherence programs. The motivation for this paper is taken from a broader action research project planned to be carried out to support an ART adherence program in Sierra Leone.