Introduction: Continuous cardiac afterload evaluation could represent a useful tool during general anesthesia (GA) to titrate vasopressor effect. Using beat to beat descending aortic pressure(P)/flow velocity(U) loop obtained from esophageal Doppler and femoral pressure signals might allow to track afterload changes. Methods: We defined 3 angles characterizing the PU loop (alpha, beta and Global After-Load Angle(GALA)). Augmentation index (AIx) and total arterial compliance (Ctot) were measured via radial tonometry. Peripheral Vascular Resistances (PVR) were also calculated. Twenty patients were recruited and classified into low and high cardiovascular (CV) risk group. Vasopressors were administered, when baseline mean arterial pressure (MAP) fell by 20%. Results: We studied 118 pairs of pre/post bolus measurements. At baseline, patients in the lower CV risk group had higher cardiac output (6.1±1.7 vs 4.2±0.6 L/min; p= 0.005), higher Ctot (2.7±1.0 vs 2.0±0.4ml/mmHg, p = 0.033), lower Aix and PVR (13±10 vs 32±11 % and 1011±318 vs 1390±327 dyn.s.cm-5; p<0.001 and p=0.016, respectively) and lower GALA (41±15 vs ± 6°; p <0.001). GALA was the only PU Loop parameterassociated with Ctot, Aix and PVR. After vasopressors, MAP increase was associated with a decrease in Ctot, an increase in Aix and PVR and an increase in alpha, beta and GALA (p<0.001 for all). Changes in GALA and Ctot after vasopressors were strongly associated (p=0.004). Conclusions: PU Loop assessment from routine invasive hemodynamic optimization management during GA and especially GALA parameter could monitor cardiac afterload continuously in anesthetized patients, and may help clinicians to titrate vasopressor therapy.