Dynamical modeling of tissue electroporation - Inria - Institut national de recherche en sciences et technologies du numérique Access content directly
Journal Articles Bioelectrochemistry Year : 2018

Dynamical modeling of tissue electroporation


In this paper, we propose a new dynamical model of tissue electroporation. The model is based on equivalent circuit approach at the tissue. Considering two current densities from cells and extracellular matrix, we identify the macroscopic homogenised contribution of the cell membranes. Our approach makes it possible to define a macroscopic homogenised electric field and a macroscopic homogenised transmembrane potential. This provides a direct link between the cell scale electroporation models and the tissue models. Finite element method adapted to the new non-linear model of tissue electroporation is used to compare experiments with simulations. Adapting the phenomenological electroporation model of Leguèbe et al. to the tissue scale, we calibrate the tissue model with experimental data. This makes two steps appear in the tissue electroporation process, as for cells. The new insight of the model lies in the well-established equivalent circuit approach to provide a homogenised version of cell scale models. Our approach is tightly linked to numerical homogenisation strategies adapted to bioelectrical tissue modeling.
Fichier principal
Vignette du fichier
201708SourceBIOJEC7041.pdf (669.14 Ko) Télécharger le fichier
Origin : Files produced by the author(s)

Dates and versions

hal-01598846 , version 1 (05-10-2017)



Damien Voyer, Aude Silve, Lluis M. Mir, Riccardo Scorretti, Clair Poignard. Dynamical modeling of tissue electroporation. Bioelectrochemistry, 2018, 119, pp.98 - 110. ⟨10.1016/j.bioelechem.2017.08.007⟩. ⟨hal-01598846⟩
581 View
540 Download



Gmail Facebook Twitter LinkedIn More