The emerging crucial point of healthcare organizations is to involve patients in autonomous monitoring their own health status by using personal ICT-based systems to manage data, and to ask for an effective cooperation with the doctor, if necessary. Two motivations urge this innovation: the growing costs of healthcare services, and the need to promote patients’ education. Therefore, the objective of this paper is to outline a Patient Guidance System (PGS) architecture to allow the patients an ubiquitous and secure management of personal health data and an easy call to the doctor in case of a critical or suspicious health situation. The PGS architecture will support an effective cooperation between the patient and the doctor in such a way to assure to the patient – either at home, or moving and/or being monitored by wearable devices – a clear interaction to get an easily understandable healthcare service.