Today’s buyer markets and lean supply chains require build-to-order assembly systems with just-in-sequence (JIS) deliveries. Simultaneously production systems have become prone to supply disturbances (i.e. events) that endanger the synchronized delivery of all JIS components to the assembly line. To uphold production sequence stability, rescheduling is frequently required. Current methods, however, make assumptions that are often insufficiently aligned with real-world problems and focus on production issues while neglecting the implications of today’s tight integration of supply chain with production processes. To this end, this contribution derives a general model of a mixed model assembly line. It then proposes and evaluates an event-driven rescheduling model for JIS deliveries. The results indicate that rework due to missing JIS components can be avoided without compromising performance.