Empirically or experimental, in every research, methodology (method, approach and technique) are employed. The methodology guides the study from the beginning to the end. What is even more important is how the researcher views and deduces the outcome through his or her analytical lens. Information systems studies are increasingly challenging, primarily because of human interactions with computing. This is mainly due to the fact that human beings are unpredictable, which has impact and influence on how systems are developed, implemented and used.In the last two decades, researchers of information systems (IS) have begun to employ socio-technical theories (lenses) in their studies. This includes younger and aspiring researchers who strive to understand the importance, as well as the application of the lenses in information systems studies. Selecting appropriate theory to underpin a study is therefore critical, primarily because it shapes and defines the results.In this article, the factors which influence and determine the selection of theories in IS studies are examined. The aim was not to compare theories that are used to underpin IS studies, rather to understand how the socio-technical theories could provide a systematic method for data analysis in the field. The article also highlights some underpinning theories used in IS studies and their usefulness to researchers seeking to identify a theoretical basis for their arguments.