It is inevitable that the dynamic is occurs in the operation of the production logistics (PL). Production logistics synchronization (PLS) can solve the dynamic of production logistics operation process by collaboration the both or among of the production, shipping and storage. Cloud manufacturing mode can quickly respond to the shortage of resources in the production logistics operation process, and provide cheap cloud resource services, such as cloud forklift. This paper is aimed at the problem for the dynamic of production logistics operation, and the dynamic of production logistics is classified. The PLS mechanism and cloud-based PLS information framework are established. By using collaboration optimization (CO) method, the optimization method of PLS is put forward. Finally, the PLS optimization model of production and storage is presented with an industrial case, and the effectiveness is also demonstrated and analyzed.