AI in Biological Modelling - Inria - Institut national de recherche en sciences et technologies du numérique Access content directly
Preprints, Working Papers, ... Year : 2016

AI in Biological Modelling

Abstract

Systems Biology aims at elucidating the high-level functions of the cell from their biochemical basis at the molecular level. A lot of work has been done for collecting genomic and post-genomic data, making them available in databases and ontologies, building dynamical models of cell metabolism, signalling, division cycle , apoptosis, and publishing them in model repositories. In this chapter we review different applications of AI to biological systems modelling. We focus on cell processes at the unicellular level which constitutes most of the work achieved in the last two decades in the domain of Systems Biology. We show how rule-based languages and logical methods have played an important role in the study of molecular interaction networks and of their emergent properties responsible for cell behaviours. In particular, we present some results obtained with SAT and Constraint Logic Programming solvers for the static analysis of large interaction networks, with Model-Checking and Evolutionary Algorithms for the analysis and synthesis of dynamical models, and with Machine Learning techniques for the current challenges of infering mechanistic models from temporal data and automating the design of biological experiments.
Fichier principal
Vignette du fichier
Fages16ai.pdf (1.45 Mo) Télécharger le fichier
Origin Files produced by the author(s)
Loading...

Dates and versions

hal-01409753 , version 1 (06-12-2016)
hal-01409753 , version 2 (11-05-2017)

Identifiers

  • HAL Id : hal-01409753 , version 1

Cite

François Fages. AI in Biological Modelling. 2016. ⟨hal-01409753v1⟩
595 View
1282 Download

Share

Gmail Mastodon Facebook X LinkedIn More