Time-coded neurotransmitter release at excitatory and inhibitory synapses - Inria - Institut national de recherche en sciences et technologies du numérique Access content directly
Journal Articles Proceedings of the National Academy of Sciences of the United States of America Year : 2016

Time-coded neurotransmitter release at excitatory and inhibitory synapses

Serafim Rodrigues
  • Function : Author
  • PersonId : 928766
Jesus M. Cortes
  • Function : Author
  • PersonId : 945124
Terrence J. Sejnowski
  • Function : Author
  • PersonId : 837622
Afia B. Ali
  • Function : Author
  • PersonId : 991222

Abstract

Communication between neurons at chemical synapses is regulated by hundreds of different proteins that control the release of neurotransmitter that is packaged in vesicles, transported to an active zone, and released when an input spike occurs. Neurotransmitter can also be released asynchronously, that is, after a delay following the spike, or spontaneously in the absence of a stimulus. The mechanisms underlying asynchronous and spontaneous neurotransmitter release remain elusive. Here, we describe a model of the exocytotic cycle of vesicles at excitatory and inhibitory synapses that accounts for all modes of vesicle release as well as short-term synaptic plasticity (STSP). For asynchronous release, the model predicts a delayed inertial protein unbinding associated with the SNARE complex assembly immediately after vesicle priming. Experiments are proposed to test the model’s molecular predictions for differential exocytosis. The simplicity of the model will also facilitate large-scale simulations of neural circuits.

Dates and versions

hal-01386149 , version 1 (22-10-2016)

Identifiers

Cite

Serafim Rodrigues, Mathieu Desroches, Martin Krupa, Jesus M. Cortes, Terrence J. Sejnowski, et al.. Time-coded neurotransmitter release at excitatory and inhibitory synapses. Proceedings of the National Academy of Sciences of the United States of America, 2016, 113 (8), pp.E1108-E1115. ⟨10.1073/pnas.1525591113⟩. ⟨hal-01386149⟩
142 View
0 Download

Altmetric

Share

Gmail Mastodon Facebook X LinkedIn More