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Conference Papers Year : 2014

Identification of Co-regulated Gene Network by Using Path Consistency Algorithm Based on Gene Ontology

Chenxiao Wang
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  • PersonId : 990814
Lizhen Liu
  • Function : Author
  • PersonId : 990815
Chao Du
  • Function : Author
  • PersonId : 990816
Jingli Lu
  • Function : Author
  • PersonId : 990817

Abstract

Recently, the reconstruction of co-regulated gene network has become increasingly popular in the area of bioinformatics. It tries to find the associated information and network topology among genes through large numbers of biological data. In this paper, we proposed a novel method PC-GO by using path consistency (PC) algorithm based on gene ontology (GO). GO provides a basis for measuring the conditional semantic similarity between genes, and then PC algorithm is applied to remove links between genes with less correlation in the network. We successfully applied our algorithm to yeast data. Experimental results show that the accuracy and integrity of the co-regulated network acquired by our method outperforms previous methods.
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hal-01383342 , version 1 (18-10-2016)

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Hanshi Wang, Chenxiao Wang, Lizhen Liu, Chao Du, Jingli Lu. Identification of Co-regulated Gene Network by Using Path Consistency Algorithm Based on Gene Ontology. 8th International Conference on Intelligent Information Processing (IIP), Oct 2014, Hangzhou, China. pp.278-283, ⟨10.1007/978-3-662-44980-6_31⟩. ⟨hal-01383342⟩
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