We present a nonlinear model predictive framework for closed-loop control of two-phase flows governed by the Cahn-Hilliard Navier-Stokes system. We adapt the concept for instantaneous control from [6,12,16] to construct distributed closed-loop control strategies for two-phase flows. It is well known that distributed instantaneous control is able to stabilize the Burger’s equation [16] and also the Navier-Stokes system [6,12]. In the present work we provide numerical investigations which indicate that distributed instantaneous control also is well suited to stabilize the Cahn-Hilliard Navier-Stokes system.