Diabetes and cognitive decline in a French cohort of patients infected with HIV-1 - Inria - Institut national de recherche en sciences et technologies du numérique Access content directly
Journal Articles Neurology Year : 2015

Diabetes and cognitive decline in a French cohort of patients infected with HIV-1

Abstract

Objective: We investigated the relationship of diabetes and prediabetes with cognitive performances, assessed through raw test and z scores and according to neurocognitive impairment (NCI) classification in a cohort of individuals infected with HIV.Methods: The ANRS CO3 Aquitaine cohort is a prospective hospital-based cohort of HIV-1–infected patients under routine clinical management in 6 public hospitals in southwestern France. Between 2007 and 2009, an ancillary study consisted of a neuropsychological battery of 10 tests at baseline and 2-year follow-up. The severity of NCI (normal, asymptomatic, mild, HIV dementia) was assessed according to international guidelines.Results: At baseline (400 patients, 33 with prediabetes, 39 with diabetes), in cross-sectional multivariable analyses, patients with diabetes performed significantly worse on 9 neuropsychological tests that assessed memory, executive functions, attention, psychomotor speed, language, and manual dexterity. Participants with prediabetes had worse performances compared with those who had normal glycemia in 5 tests. The longitudinal analysis of the association between glycemia status at baseline and change in cognitive performances over 2-year follow-up (n = 283) suggested that patients with diabetes also showed a slightly higher decline on 5 of the 10 tests, those involving executive functions and memory functioning. Glycemia status at baseline was not significantly associated with NCI severity in cross-sectional (p = 0.44) and longitudinal (p = 0.64) analyses.

Dates and versions

hal-01288876 , version 1 (15-03-2016)

Identifiers

Cite

Carole Dufouil, Laura Richert, Rodolphe Thiébaut, Mathias Bruyand, Hélène Amieva, et al.. Diabetes and cognitive decline in a French cohort of patients infected with HIV-1. Neurology, 2015, 85 (12), pp.1065-1073. ⟨10.1212/WNL.0000000000001815⟩. ⟨hal-01288876⟩
216 View
0 Download

Altmetric

Share

Gmail Facebook X LinkedIn More