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Journal Articles Health Psychology Open Year : 2016

Dyshomeostasis, obesity, addiction and chronic stress

David F Marks


When eating control is overridden by hedonic reward, a condition of obesity dyshomeostasis occurs. Appetitive hedonic reward is a natural response to an obesogenic environment containing endemic stress and easily accessible high-energy palatable foods and beverages. Obesity dyshomeostasis is mediated by the prefrontal cortex, amygdala and HPA axis. Ghrelin provides the perfect signalling for feeding dyshomeostasis, affect control and hedonic reward. Dyshomeostasis plays a central role in obesity causation, the addictions, chronic conditions and in persons with diverse bodies. Prevention and treatment efforts that target sources of dyshomeostasis provide ways of reducing adiposity, ameliorating addiction, and raising the quality of life in people suffering chronic stress.
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hal-01274337 , version 1 (16-02-2016)


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  • HAL Id : hal-01274337 , version 1


David F Marks. Dyshomeostasis, obesity, addiction and chronic stress. Health Psychology Open, 2016, 2 (2). ⟨hal-01274337⟩
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